Don't expect to see Jennifer Aniston going on anymore Mexican vacations with Chelsea Handler!

Aniston was so appalled at what Handler said about Angelina Jolie on her late-night talk show that she is starting to distance herself from the comedian.

Jennifer Aniston No Longer Friends With Chelsea Hanlder?!

A friend of Chelsea's told Popeater.com, "Jen and Chelsea haven't officially fallen out but they certainly won't be going on vacation together for a long time unless Chelsea promises to never talk about Angelina again. She understands that what Chelsea did was out of loyalty, but it didn't help. In fact, it made things worse."

Related Article: Chelsea Handler Slams Angelina Jolie

Unfamiliar with what exactly Chelsea said about Jolie? During a recent performance, Handler said, "She can rescue as many babies from as many countries as she wants to. I don't f***ing believe you...she gives interviews, 'I don't have a lot of female friends.' Cause you're a f***ing c**t...you're a f**king b***h."

Jennifer Aniston No Longer Friends With Chelsea Hanlder?!

Related Article: Chelsea Handler Talks Backstage At The 2010 VMAs!

The remarks were made not too long after Chelsea spent Thanksgiving with Jennifer in Mexico. A friend of Aniston's said, "Jen is a very private person. It's one thing to crash Angelina in private; it's another to do it in public. Chelsea should have known better and is feeling Jen's cold shoulder for her mistake."

What do you think of Chelsea's remarks?

Photos Courtesy of Fame Pictures