How do you take someone who's been on the air for more than 25 years, raised and donated more than $500 million to charity, and become the most powerful woman in the world, and narrow her life down to the 10 best moments?

To celebrate Oprah Winfrey's 59th birthday, that's what we at Hollywire were tasked with. Our painstaking deliberation involved plenty of yelling, crying and throwing things across the office, but we've managed to handpick the 10 single greatest moments of Oprah's career.

Check out our roundup after the jump!

After more than 35 years of making movies, Denzel Washington is still creating some of his best work ever.

Most people would be content with dozens of successful films and a couple of Academy Awards, but Denzel dug deep with his most recent flick Flight, where he played drug-addicted airline captain William "Whip" Whittaker. The role was already nominated for a Golden Globe and looks very likely to receive an Oscar nomination as well. In honor of his 58th birthday today, check out 10 reasons why Denzel remains one of Hollywood's strongest leading men!

Which charity has Denzel been a spokesman of for nearly 20 years? Find out after the jump!

In an industry where you're often over the hill in your 30s, Will Smith is still going strong at 44!

He celebrates that birthday milestone today as the former rapper, current actor and perpetual hottie proves that age ain't nothing a number. In honor of his birthday, check out our favorite Big Willie music videos from over the years!